Initiating Coordination

Initiating inhibition

A recent publication by Schellmann et al. (2002) in The EMBO Journal has provided important insights into the control of cell fate and pattern formation in plants. To study the underlying molecular mechanisms, the authors made use of the development of root hairs and trichomes in Arabidopsis thaliana. A. thaliana trichomes are large, unicellular structures that project out from the shoot epider...

Initiating Development

Characteristics of patients initiating raloxifene compared to those initiating bisphosphonates

BACKGROUND Both raloxifene and bisphosphonates are indicated for the prevention and treatment of postmenopausal osteoporosis, however these medications have different efficacy and safety profiles. It is plausible that physicians would prescribe these agents to optimize the benefit/risk profile for individual patients. The objective of this study was to compare demographic and clinical character...

Initiating an antitumor attack.

Designing proteins with cavities In de novo protein design, creating custom-tailored binding sites is a particular challenge because these sites often involve nonideal backbone structures. For example, curved b sheets are a common ligand binding motif. Marcos et al. investigated the principles that drive b-sheet curvature by studying the geometry of b sheets in natural proteins and folding simu...

Initiating lung cancer

SCIENCE sciencemag.org P H O T O : C O R S IC A S M A R T / IS T O C K This is a case of the nocebo effect seriously interfering with medical treatment. Tinnermann et al. investigated whether value information such as the price of a medication can further modulate behavioral nocebo effects and the underlying neural network dynamics (see the Perspective by Colloca). They used brain imaging to ch...